St. Charles Historic Main Street
Much of St. Charles' history can be found in the buildings lining our historic Main Street which is listed on the National Register of Historic Places. From the site of its first settler, Louis Blanchette, to innovators at OPO Startups, there is a bit of everything! From fur traders and blacksmiths, from Lewis and Clark's Corps, and Missouri’s first Statesmen, these are the people that bring these buildings to life and share the history of St. Charles. As the Missouri River gave way to the Boone's Lick Road and the development of the railroads, St. Charles is part of America's westward expansion and the beginning of Missouri's Statehood.